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Pancreas Cancer

Switching chemos too quick? was posted 04/30/2005 11:54 pm by TKC!
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Hi all,

I have a question about switching chemos. Starting in Dec., my Mom was on Gemzer, Avastin & Oxiliplatin. Her numbers steadily dropped (then leveled a bit), however, her white blood counts & platlets were low and she received frequent transfusions.

In March, the doctor removed the Oxiliplatin (because of her low platlets) and added Xeloda to the mix (so she was receiving Gemzer, Avastin, and Xeloda). She was on this combo for 2 rounds (3 weeks apart). Her CA19-9 dropped while on this combo.

At her last visit (April 27), the doc decided to drop the Gemzer and add Tarceva. So, she is now on Avastin, Tarceva, and Xeloda. He said he did this because her platlet count continues to be low not because the chemo wasn't working.

My questions are....

1. This seems to be a lot of switching things around. Has anyone else been switched this frequently? Is this normal?

2. By being on so many combos, is Mom likely to develop a tolerance for them, so in a later stage we will run out of options?

3. Is anyone else on the Avastin, Xeloda, Tarceva combo? If so, could you share your side effects?

Thanks always for your help. Prayers are with you tonight. Laura

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