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Discussion Boardinfection/inflammation - John was posted 07/05/2001 04:02 pm by Elizabeth W.
E-mail Address: firstname.lastname@example.org
John, I would like to add to the infection/inflammation possibility line by
giving part of my story and my thinking.
I had intermittent, small elevations of AST and ALT (liver function tests
on standard blood chemistries) for 15 years before my stage 4A distal
common bile duct cancer was found on my 52nd birthday. (I had pain near the
navel for at least 5 years before the Whipple.) In those 15 years,
I was tested for various liver diseases at various times and none of the
tests were ever positive. Recently, I visited a liver specialist, Dr. Mezey,
at JHH for another problem (turned out to be liver reaction to sepsis from
bacterial overgrowth in Whipple 'blind loop') and I asked about my 15 year
history of slightly elevated AST and ALT (and LDH as well). Dr. Mezey
said I likely had intermittent blockages in my bile duct probably caused
by infection/inflammation, and at those times the bile backed up into the
liver to cause the elevated AST and ALT. Dr. Mezey said that if I had been
his patient he would have watched me closely and found the bile duct cancer
much sooner. That would have been great. But, I am in favor of removing the
infection or source of inflammation before a cancer develops. Maybe you
can figure out how to do it. I have talked with Dr. Hruban (the JHH
site) and he talks about using bile to test in the research setting.
I too hope that further testing will confirm a benign process. Elizabeth
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