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Gleevec - tech. question was posted 05/11/2001 03:24 pm by Elizabeth W.
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Gleevec (STI571) for chronic myeloid leukemia has been approved. says it stops the activity of the abnormal protein, BCR-ABL, that is made by the leukemia cells for proliferation. The article says that the new drug is being tried on several solid tumor cancers. Is the abnormal protein, BCR-ABL, expressed by other solid tumors or can Gleevec stop some other abnormal proteins? And most importantly, can a distal common bile duct tumor that is formulin(sp?)-fixed be tested for these molecular characteristics (abnormal proteins)? Thanks. Elizabeth W.

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