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Pancreas Cancer

new paper on early detection was posted 09/06/2017 04:33 pm by Dr. Hruban
E-mail Address: rhruban@jhmi.edu

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New paper on the early detection of pancreatic cancer. Scientists in the Sol Goldman Pancreatic Cancer Research Center report, in the Proceedings of the National Academy of Sciences (www.pnas.org) a new approach to the earlier detection of pancreatic cancer. In the September 5th Early Edition of the journal, Joshua Cohen and colleagues report that a blood test consisting of a combinaition of 'circulating tumor DNA (ctDNA)' and protein markers can detect pancreatic cancer at an early, potentially curable, stage. The team tested 221 patients with surgically resectable pancreatic ductal adenocarcinomas and 182 control patients without known cancer. The use of ctDNA marker (KRAS) in conjunction with four protein biomarkers was able to detect two-thirds (64%) of the surgically resectable cancers. Only one of the 182 controls had a false positive test. .The authors concluded that 'This combinatorial approach may prove useful for the earlier detection of many cancer types.' A nice advance in the fight against pancreatic cancer!

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