|*DISCLAIMER: This page is an unmoderated forum, and the opinions expressed herein do not necessarily reflect the viewpoint of The Johns Hopkins Medical Institutions. Patients are advised to consult their personal physicians before making any medical decisions. |
Alpha-Lipoic Acid / Low-Dose Naltrexone (ALA/N) The Integrative Medical Center of New Mexico, (located in Las Cruces) previously reported the long-term survival of a male patient with pancreatic cancer metastasized to the liver, treated with intravenous alpha-lipoid acid and oral low-dose naltrexone (ALA/N) (and a healthy lifestyle program) without any toxic adverse effects. The man was alive and well 78 months after initial treatment (Berkson 2006) even though he was told by a reputable oncology center in October 2002 that there was little hope for his survival.
Clinical Studies with ALA/N Recently three new patients with metastatic pancreatic cancer were treated with the ALA/N protocol at the same center. In 2010, it was reported that the first patient is alive and well 39 months after presenting with pancreatic adenocarcinoma with metastases to the liver. The second patient, also with pancreatic adenocarcinoma with metastases to the liver, was treated with the ALA/N protocol and after 5 months of therapy, PET scan showed no evidence of disease. The third patient, in addition to his pancreatic cancer with liver and retroperitoneal metastases, has a history of B-cell lymphoma and prostate adenocarcinoma. After 4 months of the ALA/N protocol his PET scan showed no evidence of cancer. ALA/N exerts multiple anti-cancer effects including reducing oxidative stress, stabilizing NFkB, stimulating apoptosis, inhibiting tumor cell proliferation and modulating an immune response (Berkson 2009)
Berkson and colleagues (2009) believe that the results from their ALA/N integrative protocol warrant clinical trials, stating that “given its lack of toxicity at levels reported it may have the possibility of extending the life of a patient who would be customarily considered to be terminal.”
The ALA-LDN protocol comprises alpha-lipoic acid (ALA) (300 to 600 mg intravenously twice weekly), low-dose naltrexone (Vivitrol™) (3 to 4.5 mg at bedtime), and orally, ALA (300 mg twice daily), selenium (200 micrograms twice daily), silymarin (300 mg four times daily), and vitamin B complex (3 high-dose capsules daily). In addition, a strict dietary regimen, stress-reduction and exercise program, and a healthy lifestyle are essential.
Reply to this message | Return to Main Message List