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Unfortunately, many of us pick up infections during this process. The most common entrance site is the port, since unless everyone accessing it is impeccable in their clean technique, it is a runway straight into the bloodstream. Usually it is bacteria from the skin that get into the port. Or from anyone's hands who were not clean when they were messing with it.
Did the docs say why they thought a bacteria from the bowels/gut caused the sepsis? This is NOT as common for us at all. Did they tell you the name of the bacteria?
Unfortunately, many 'gut' bacteria cause infections in us from people not washing their hands after they use the bathroom. We can infect ourselves that way!
Did he have a low white blood cell count? After chemo this happens to many of us and makes us more susceptible to infection. BUT this almost never happens after only one chemo treatment, especially in someone your husband's age.
At this point, he needs to recover and get his strength back. While he is getting antibiotics at home, I assume he has home nursing coming. I strongly recommend you ask for them to start some home PT to get him strong/recovered quickly if he lost some ground. At this point focus on eating well, sleeping well, and recovery. I realize it is very anxiety provoking worrying about the cancer growing, but you will get through this bump and if the chemo is going to work, it will likely still work. It is too soon to know if the chemo has worked from only one treatment... not enough.
Hang in there.
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