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Pancreas Cancerneuropathy was posted 04/30/2012 10:45 am by Anonymous
Cisplatin is the sister medicine to Oxaliplatin. For some people, it is
rougher on the kidneys. While it does not have the COLD sensitive neuropathy
(painful/uncomfortable sensations when your skin/mouth is exposed to cold
things) it does still cause neuropathy. This neuropathy can actually be more
permanent then the neuropathy with Oxaliplatin. It is the more traditional
neuropathy where you slowly develop numbness/tinglings in the toes and
fingers, and it can slowly spread over time. I have heard that as you
develop the cisplatin neuropathy, it is less likely to reverse completely, so
that's why the doctors have to carefully monitor your neuropathy over the
time.... and if it gets bad enough to interfere with function (clumsy
buttoning shirt etc...), they need to stop using cisplatin.
We debated using cisplatin or oxaliplatin. Some insurance companies don't
want to pay for oxaliplatin. For us, our doctors favored oxaliplatin
slightly, and in the end we thought the neuropathy risk was slightly less
with Oxi. But I admit, the cold sensitive neuropathy was really
uncomfortable for us. However, Oxaliplatin had the evidence to use
calcium/magnesium infusions before/after infusion of Oxaliplatin to decrease
the chance of developing the neuropathy. No idea if it helped, but may have.
I don't think the studies have been completed to see if calcium/magnesium
helps prevent neuropathy with cisplatin.
We eventually had to stop using the Oxaliplatin because of disease
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