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Pancreas Cancer

neuropathy was posted 04/30/2012 10:45 am by Anonymous
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Cisplatin is the sister medicine to Oxaliplatin. For some people, it is rougher on the kidneys. While it does not have the COLD sensitive neuropathy (painful/uncomfortable sensations when your skin/mouth is exposed to cold things) it does still cause neuropathy. This neuropathy can actually be more permanent then the neuropathy with Oxaliplatin. It is the more traditional neuropathy where you slowly develop numbness/tinglings in the toes and fingers, and it can slowly spread over time. I have heard that as you develop the cisplatin neuropathy, it is less likely to reverse completely, so that's why the doctors have to carefully monitor your neuropathy over the time.... and if it gets bad enough to interfere with function (clumsy buttoning shirt etc...), they need to stop using cisplatin.

We debated using cisplatin or oxaliplatin. Some insurance companies don't want to pay for oxaliplatin. For us, our doctors favored oxaliplatin slightly, and in the end we thought the neuropathy risk was slightly less with Oxi. But I admit, the cold sensitive neuropathy was really uncomfortable for us. However, Oxaliplatin had the evidence to use calcium/magnesium infusions before/after infusion of Oxaliplatin to decrease the chance of developing the neuropathy. No idea if it helped, but may have. I don't think the studies have been completed to see if calcium/magnesium helps prevent neuropathy with cisplatin.

We eventually had to stop using the Oxaliplatin because of disease progression.

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