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Pancreas Cancer

Agree! was posted 03/31/2012 01:48 pm by Anonymous
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This is also what bothers me about posts of 'risk factors'. I guess the hope is that if we know them, we can educate people on how to try to optimize them to decrease our chances. It almost seems silly because they are all things we already know that are important for decreasing our chance of most cancers!

But with PC.... as with all cancers (some more then others...).... it really comes down to genetics. Complicated genetics, in the vast majority of cases. And we can't change our genes.

So the problem with the lists of risk factors is they don't include how significant each relative risk factor is for developing the disease. These numbers are also confusing for most people to interpret anyway, so we just keep things 'simple' with lists.

For most of us, it comes down to our genes and random bad luck. Some of us are more at risk from birth by inheriting some genes very significant for increasing cancer risk (eg. BRCA gene mutants...), but even those folks don't always get PC, and most of us don't carry these mutant genes. It all comes down to 100 other genes... or 1000 other genes.... or 10,000 other genes.... and one errant cell making a mistake during cell division that doesn't get correct properly..... and then perhaps another that allows it to grow or mutate back into a stem cell... or ..... there are many possibilities, and so so so hard to prevent or repair each possible permutation. That is why treating cancer is so hard. There are many different ways that things can go wrong and then lead down the 'same' cancer path. So somehow we have to figure out how to 'fix' all of them...

What we really need first is to educate ourselves and the public with what the symptoms of PC are so people know when to be concerned, and be advocates for improving funding for research into PC early detection. As we know, the universal 'cure' for cancer is far away, and PC is behind many others in this specific regard. So far now we MUST focus on earlier detection so it can be most effectively attacked at the only time most of us will have hope for a cure. This is how the breast cancer movement started, and they have been very effective. And even without better 'cures', breast cancer has dropped it's lethality rate dramatically.

Just my 2 cents.

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