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Pancreas Cancer

Maybe this will help was posted 12/31/2010 11:08 am by Shelley
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I was reading your posts above regarding the doctor not being motivated to try different treatments. I don't know if this will help but I've posted an e-mail from Dr. Fine regarding the most recent GTX protocol. Our doctor kept saying that GTX would be too harsh until we brought him this e-mail. After he read this, he agreed to try it. Mark found GTX easy to handle (easier than the Gem+Cisplatin and easier than the Irinotecan+Xeloda that he's on currently. You never know how you're going to react to a chemo until you try it. Some people really struggle with the GTX, others have found it easy to handle.

It is not harsh and easier than FOLFOX in my latest version: xeloda-1000mg twice a day orally total dose for 14 days ;days 4 and 11-gemzar at 600mg/m2 over 60 mins followed by taxotere at 30mg/m2 over 60 mins. Then. 1 week off equals 1 cycle.Give 3 cycles and scan.The actual dose of xeloda pills is 600mg/m2 twice a day with a cap at 1000 mg twice a day for 14 days.This regimen is easily tolerated and we are reporting in 2009 ASCO abstract a response rate of 40% with progression free survival of 7.0 months;median overall survival of 14.2 months; and 12,18,24,30 and 36 month survivals of 59%,34%,15%,7% and 5%, respectively, in 41 metastatic pancreatic patients of which 80% had liver metastases.This was from our recently completed prospective trial analyzed by intent to treat and using RECIST parameters. Show this to your oncologist.Robert Fine



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