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Pancreas Cancer

Posting Anonymously was posted 09/05/2010 06:23 pm by gpawelski
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In regards to all my relationships Anonymous, I receive no financial support from any drug company, laboratory, medical equipment manufacturer, insurance carrier, professional organization, or hospital grroup. To paraphrase Martin Luther King, Jr., “a scientific communication should be judged on the quality of its content and only secondarily, or not at all, on the qualifications of its author.

As a cancer patient advocate, I’ve been interested in and studied the aspects of cell function analysis (harken back to my college days studying biology) for a number of years, like anyone would have an interest in molecular science or biological science. My point with respect to cell function analysis is to educate patients and others (even doctors) that such science and technology exists, and might be very valuable.

I get nothing out of my endeavors except the satisfaction of knowing that I’ve helped to increase the knowledge of informed consent. I get no pay, no lectureships, no junkets, not even any free meals.

Molecular profiling is an indirect approach to chemotherapy selection which examines a single process (pathway) within the cell or a relatively small number of processes (pathways). It’s aim is to determine only if there is evidence of a theoretical predisposition to drug susceptibility. In this regard, molecular profiling is a “static” profiling approach. In contrast, the functional profiling approach involves real-time assessment of ‘fresh’ living cancer and endothelial cell behaviors in the presence or absence of anti-cancer or anti-angiogenic drugs. This method accounts not only for the existence of genes and proteins but also for their functionality and for their interaction with other genes, other proteins and other processes occurring within the cell. You can take advantage of profiling the entire cell to measure the interaction of the entire genome (not just one pathway or a couple of pathways).

You can study all the pathways you want. Although molecular testing currently is limited in its reliability as a clinical tool, the testing can be important in research settings such as in helping to identify rational targets for development of new anti-cancer drugs. However, for drug selection, there are many pathways to altered cellular (forest) function (hence all the different “trees” which correlate in different situations). Functional profiling the whole cell measures what happens at the end (the effects on the forest), rather than the status of the individual trees.

I post my own name or moniker that everyone is familiar with. I don't have to hide behind Anonymous!

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*DISCLAIMER: This page is an unmoderated forum, and the opinions expressed herein do not necessarily reflect the viewpoint of The Johns Hopkins Medical Institutions. Patients are advised to consult their personal physicians before making any medical decisions.
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