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Discussion Boardcholangiocarcinoma was posted 09/11/2000 05:22 pm by peter argani
E-mail Address: email@example.com
Dear bda: i am of course very sorry to hear that your husband died of bile
duct carcinoma. unfortunately, this type of cancer remains one of the most
difficult to treat by the chemotherapy that is available to oncologists even
today. most bile duct cancers arise without any predisposing factors (such
as a history of primary sclerosing cholangitis), so their cause is unknown.
much of the work being done today centers on trying to figure out the changes
in the DNA in the tumor cells which make them so aggressive. we are trying
to do this here at hopkins, and are slowly making progress in deciphering
what genes are inactivated in these tumors. one we learn this, we will have
a chance to design drugs that can reverse the effects of these genetic
changes. it is fortunately very unlikely that your sons would be susceptable
to bile duct cancer, as hereditary forms of this disease are rare. symptoms
that might suggest a problem in the biliary tree (not necessarily cancer)
would include jaundice, itching, weight loss, and pain in the right abdomen.
my best wishes are with youpeter argani
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